在一个大型跨国潜在狼队列中,爆发和持续活跃疾病的频率和决定因素
Yanjie Hao1, Dylan Hansen2, Worawit Louthrenoo3
1The University of Melbourne and St Vincent's Hospital Melbourne, Melbourne, Victoria, Australia, and Peking University First Hospital, Beijing, China.
ACR open rheumatology
|February 27, 2025
概括
持续活跃性疾病 (PAD) 和发作在系统性红斑狼 (SLE) 中很常见. PAD影响了近一半的患者,需要超越仅仅是爆发评估的监测,以获得最佳的疾病控制.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 内部医学 内部医学
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,具有多种不同的临床表现.
- 疾病活动模式,包括复发复发,爆发和持续活跃疾病 (PAD),显著影响患者的结果.
- 持续活跃疾病 (PAD) 是一种未经研究的SLE活动模式,可能导致器官损伤.
研究的目的:
- 为了确定SLE.患者的大量队列中爆发和持续活跃疾病 (PAD) 的频率.
- 确定与SLE发作和PAD发展相关的临床和人口因素.
- 开发和验证SLE患者发作和PAD预测模型.
主要方法:
- 使用SELENA-SLEDAI爆发指数来定义爆发.
- 持续活跃疾病 (PAD) 被定义为在两个或两个以上连续访问时的SLEDAI-2K分数≥4.
- 开发和验证了多变量逻辑回归模型,以预测爆发和PAD.
主要成果:
- 在2.8年内,3811名SLE患者中有56.2%出现了发作,46.9%患有PAD.
- 炎和关节炎是常见的发作特征;脏或粘膜皮肤活动是PAD的特征.
- 爆发的预测因素包括低GDP,吸烟,关节炎,炎和低补充;PAD是由活动和较高的SLEDAI-2K得分预测的. 低疾病活性状态 (LLDAS50) 对两者都有保护作用.
结论:
- 发烧和PAD在SLE中普遍存在,并与器官损伤相关.
- 爆发和PAD有不同的临床特征和预测因素.
- 单独评估发作不足以确定所有SLE患者的疾病控制不足,因为9.7%的患者没有发作而表现出PAD.
相关概念视频
Autoimmune Disorders
378
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
378
Steps in Outbreak Investigation
102
In the ever-evolving field of public health, statistical analysis serves as a cornerstone for understanding and managing disease outbreaks. By leveraging various statistical tools, health professionals can predict potential outbreaks, analyze ongoing situations, and devise effective responses to mitigate impact. For that to happen, there are a few possible stages of the analysis:
102
Genome-wide Association Studies-GWAS
12.3K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
12.3K


