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评估Ya That Opchoei混合物的低血糖效率和质量保证
Thaweesak Juengwatanatrakul1, Kusuma Jitsaeng1, Rawiwun Kaewamatawong1
1Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Warin Chamrap, Ubon Ratchathani, Thailand.
Journal of evidence-based integrative medicine
|February 27, 2025
概括
传统的泰国草药疗法Ya That Opchoei (YTO) 通过抑制关键酶和增强葡萄糖吸收,有效降低血糖. 它的生物活性化合物被识别和量化,确保在糖尿病管理中安全使用.
科学领域:
- 药理学和传统医学的医学.
- 自然产品化学 自然产品化学
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病,在泰国传统医学中被称为Madhumeho,与不平衡的生活元素有关.
- 传统上,Ya That Opchoei (YTO) 是一种多草药混合物,用于控制糖尿病症状.
研究的目的:
- 为了评估Ya That Opchoei (YTO) 混合物的低血糖潜力.
- 对YTO的生物活性成分进行定性和定量分析,以确定其安全性和有效性.
主要方法:
- 在体外酶抑制测定α-葡萄糖酶和α-氨基酶.
- 对C-分泌和葡萄糖吸收刺激的评估.
- 液体染色学-质谱学 (LC-MS) 用于成分识别.
- 高性能液体色谱 (HPLC) 用于特定生物活性化合物的量化.
主要成果:
- YTO显示出明显的α-葡萄糖酶 (IC50 0.05 mg/mL) 和α-氨基酶 (IC50 0.04 mg/mL) 的抑制.
- YTO (2.22 mg/mL) 显著增加了C-分泌,并刺激了葡萄糖的吸收.
- 在LC-MS中,发现了来自Amomum testaceum,Cinnamomum bejolghota,C. burmanii,Syzygium aromaticum和Glycyrrhiza glabra的成分.
- 通过HPLC量化了甘油酸,尤根醇,肉酸,肉甲和氨酸;氨酸的含量处于安全的每日摄入量范围内.
结论:
- 这项研究证实了Ya That Opchoei (YTO) 混合物的显著低血糖潜力.
- 详细分析提供了质量控制框架,确保YTO在糖尿病管理中的治疗用途的安全性.
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