患者对三级暴露复发性或耐火性多发性骨髓瘤治疗的偏好:一个离散选择研究
Sikander Ailawadhi1, Timothy J Inocencio2, Carol Mansfield3
1Division of Hematology/Oncology, Mayo Clinic, Jacksonville, FL, USA.
Future oncology (London, England)
|February 27, 2025
概括
患有复发性/耐药性多发性骨髓瘤的患者更喜欢优先考虑整体生存的治疗方法,并尽量减少严重感染和住院治疗. 这些因素对于三级暴露患者的治疗决策至关重要.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 卫生经济学 卫生经济学
背景情况:
- 多发性骨髓瘤 (MM) 是一种血液性恶性瘤.
- 复发性和/或耐火性多发性骨髓瘤 (RRMM) 存在重大治疗挑战.
- 三级暴露 (TCE) 患者的治疗选择有限.
研究的目的:
- 量化患者对TCE RRMM新型治疗方法的关键属性的偏好.
- 了解患者对疗效,安全和治疗物流的优先考虑.
主要方法:
- 一个离散选择实验被用来引起患者的偏好.
- 评估了七个治疗属性:ORR,OS,CRS风险,ICANS风险,严重感染风险,管理和初次住院.
主要成果:
- 总生存率 (OS) 是最关键的属性,其次是严重感染风险,初次住院和客观反应率 (ORR).
- 患者更喜欢减少住院日数和现成的治疗方案,而不是类似于CAR T细胞的疗法.
结论:
- 对TCE RRMM的治疗决定应该平衡有效性,安全性和以患者为中心的后勤因素.
- 患者的偏好突出了生存,安全和可管理的治疗管理的重要性.
更多相关视频
10:04Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
13.0K
09:57Comprehensive Protocol to Sample and Process Bone Marrow for Measuring Measurable Residual Disease and Leukemic Stem Cells in Acute Myeloid Leukemia
Published on: March 5, 2018
29.1K
相关概念视频
02:50Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
02:57Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K