相关实验视频

Updated: May 25, 2025

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications
08:19

Solid Lipid Nanoparticles SLNs for Intracellular Targeting Applications

Published on: November 17, 2015

17.1K

配方,优化和ex vivo透研究里托纳维尔装载的固体脂质纳米颗粒

Prathap Madeswara Guptha1,2, Narahari N Palei3, Surendran Vijayaraj4

  • 1Amity Institute of Pharmacy, Amity University, Gwalior, Madhya Pradesh, India.

Current pharmaceutical design
|February 27, 2025
PubMed
概括

优化里托纳维尔装载的固体脂质纳米颗粒 (SLN) 显著提高了药物的透性. 这些RTV-SLN显示出作为改善抗病毒药物的口服生物可用性的有希望的载体的潜力.

关键词:
盒子-Behnken设计的设计.里托纳维尔 (Ritonavir) 是一种药物.结晶指数的指数是外体生体研究研究.透性 透性的固体脂质纳米粒子 固体脂质纳米粒子

更多相关视频

Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs18:46

Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs

Published on: December 9, 2010

13.2K
A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM13:54

A Workflow for Lipid Nanoparticle LNP Formulation Optimization using Designed Mixture-Process Experiments and Self-Validated Ensemble Models SVEM

Published on: August 18, 2023

4.3K

相关概念视频

Methods for Studying Drug Absorption: In situ01:09

Methods for Studying Drug Absorption: In situ

In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
195
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
670
Factors Influencing Drug Absorption: Drug Dissolution01:27

Factors Influencing Drug Absorption: Drug Dissolution

The pharmacokinetic journey of drugs from solid oral dosage forms into systemic circulation is multifaceted. It begins with disintegration, a prerequisite ensuring a solid dosage form's subdivision into minute particles. Dissolution occurs next as these granulated entities solubilize in gastrointestinal fluids. This solubilization is crucial for the succeeding stage, permeation, which describes the traversal of the drug across the intestinal membrane and its subsequent entry into the blood...
399