表观遗传学如何通过DNA甲基化影响中风风险和结果:系统性审查
Cristina Gallego-Fabrega1, Natalia Cullell1,2,3, Israel Fernández-Cadenas1
1Stroke Pharmacogenomics and Genetics Group, Institut de Recerca Sant Pau (IR SANT PAU), Barcelona, Spain.
概括
缺血性中风 (IS) 患者的DNA甲基化 (DNAm) 模式表明他们生理上较老,可能提供新的治疗点. 了解DNAm DNA的理解
科学领域:
- 表观遗传学和分子生物学
- 神经学和中风研究 神经学和中风研究
- 基因组学和生物信息学
背景情况:
- 基因甲基化 (DNAm) 是一种关键的表观遗传机制,其在复杂疾病中的作用越来越受认可.
- 缺血性中风 (IS) 是导致残疾的主要原因,了解其潜在的分子机制对于改善治疗至关重要.
- 表观遗传修饰,特别是DNAm,是可逆的,为治疗干预提供了潜力.
研究的目的:
- 系统地审查和综合有关DNA甲基化与缺血性中风风险和预后有关的现有数据.
- 探索DNA甲基化作为IS治疗点的潜力.
- 编译从研究IS的DNAm的无假设研究中得出的结果.
主要方法:
- 系统的文献审查遵循PRISMA指南.
- 搜索了PubMed和Cochrane数据库的相关研究.
- 包括 459 项鉴定中的 34 项研究,重点关注无假设的方法.
主要成果:
- 缺血性中风患者表现出表观遗传模式,表明他们在生物学上比他们的时间年龄更老.
- 独特的DNAm模式与发展IS的风险和患者的结果有关.
- 基因型阵列主要用于DNAm分析,主要是血液样本,大多数研究重点是欧洲队列.
结论:
- 在IS患者的DNA甲基化特征提供了对生物衰老和疾病关联的见解.
- 已识别的DNAm模式对开发新型治疗策略,包括流行病药物,具有前途.
- 对DNAm的进一步研究可能会导致预防和治疗缺血性中风的有针对性的干预措施.
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