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在斋月斋戒之后,在中国的巴基斯坦外籍人士肠道微生物组的重塑

Hafiz Arbab Sakandar^1,2,3, Feiyan Zhao^1,2,3, Jiahe Kang^1,2,3

¹Key Laboratory of Dairy Biotechnology and Engineering, Ministry of Education Inner Mongolia Agricultural University Hohhot China.

Food science & nutrition

|February 27, 2025

概括

时间限制间歇性禁食 (TRIF),就像斋月禁食一样,显著改变了肠道微生物组的组成和功能. 这些变化会影响微生物的新陈代谢,为对抗代谢障碍的干预提供了洞察力.

科学领域:

微生物学微生物学
人类营养人类营养
代谢健康代谢健康

背景情况:

时间限制间歇性禁食 (TRIF) 越来越多地被认为具有管理超重,肥胖和代谢综合征的潜力.
肠道微生物群在人类健康中起着至关重要的作用,影响各种代谢过程.
对TRIF对肠道微生物群的影响的研究是有限的,特别是在发展中国家和欠发达人口中.

研究的目的:

研究TRIF,特别是斋月禁食 (16:8) 对肠道微生物组合和功能概况的影响.
分析在斋月斋戒期间和之后,在居住在中国的巴基斯坦外籍人士中微生物群落的变化.
探索将肠道微生物组变化与代谢健康联系起来的潜在机制.

主要方法:

观察性研究涉及在中国的巴基斯坦外籍人士,他们正在斋月禁食 (16:8).
在不同时间点对肠道微生物组合 (α多样性和结构变化) 的分析.
使用预测的代谢途径对微生物群落的功能概况.
统计分析以确定细菌群和代谢功能的显著变化 (p < 0.05).

主要成果:

在TRIF期间观察到肠道微生物群α多样性的显著变化.
肠道微生物结构在禁食期结束时比起开始时显示出更明显的变化.
包括*Clostridium perfringens*,*Coprococcus comes*和*Lactococcus lactis*在内的特定细菌表现出显著的变化.
TRIF显著影响了氨基酸,碳水化合物和能量代谢,以及糖甘生物合成和辅因子/维生素代谢.
预测的代谢途径揭示了皮里多克萨,谷氨酸,素,酸和短链脂肪酸的实质性差异.

结论:

斋月禁食的例子是TRIF,它会导致肠道微生物组的组成和功能发生显著的变化.
这些微生物组变化与与人类健康相关的关键代谢途径的变化有关.
这些发现表明,针对微生物组量身定制的干预措施有可能改善特定人群的代谢健康,比如巴基斯坦外籍人士.
需要进一步的研究,以阐明肠道微生物组稳定性背后的精确机制及其在改善代谢障碍方面的作用.

关键词:

拉马达拉马达拉马达拉马达拉马达拉马达拉马达拉马达拉马达拉马达拉马达拉马达拉马达拉马达拉马达拉马达拉马达拉马达我们的肠道微生物群.代谢功能代谢功能有时间限制的间歇性禁食.

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