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脑电图的α/β特征作为量化腰椎间盘的患者疼痛的生物标志物

Rumei Li^1,2, Wanqi Shao³, Shumei Zhao³

¹Nanjing Research Institute of Electronics Technology, Nanjing, China.

Frontiers in neuroscience

|February 27, 2025

概括

脑电图 (EEG) 的变化与治疗后腰椎间盘 (LDH) 患者的疼痛减轻相关. 阿尔法/贝塔EEG特征显示了评估LDH疼痛的生物标志物的潜力.

科学领域:

神经科学是一个神经科学.
疼痛管理疼痛管理
传统中国医药传统中国医药

背景情况:

客观的疼痛评估对于临床管理至关重要.
电脑电图 (EEG) 显示出作为主观疼痛感知的非侵入性生理指标的前景.

研究的目的:

为了分析腰椎间盘 (LDH) 的EEG变化,用小针刀治疗的患者.
探索使用EEG作为LDH疼痛评估指标的可行性.

主要方法:

从20名LDH患者 (治疗前和治疗后) 和20名健康对照 (HC) 中记录了静止状态的EEG.
使用连续波段变换的EEG光谱分析在四个频段 (θ,α,β,γ) 中确定了功率比.
在特定的大脑区域分析了EEG特征和疼痛尺度 (VAS,mJOA) 之间的相关性.

主要成果:

小针刀治疗显著降低了疼痛评分 (VAS: 32.86%,mJOA: 38.41%).
与HC相比,LDH患者表现出不同的EEG功率比率,具有改变的alpha,theta和beta频段活性.
阿尔法/贝塔脑电图特征与前额和顶部区域的VAS和mJOA得分有显著的负相关性.

结论:

在LDH患者和HC患者之间,EEG功率比率显著不同,并且受到治疗的影响.
额头和额头的α/βEEG特征与主观疼痛相关,这表明LDH可能是短期疼痛生物标志物.

关键词:

生物标志物生物标志物电脑脑电图 (EEG) 是一种电脑电图.腰椎椎间盘的发生振荡的振荡是如何发生的疼痛疼痛疼痛疼痛功率比率是指功率比率.

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