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侵袭性导管性乳腺癌中的瘤芽:与临床病理学预后参数和激素受体状态的相关性

Sachin Sebastian Francis¹, Swati Sharma¹

¹Department of Pathology, Center of Basic Sciences, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Pathology oncology research : POR

|February 27, 2025

概括

乳腺癌中的外周瘤芽 (PTB) 与更差的预后有关,与淋巴血管入侵和淋巴结参与相关. 瘤内芽 (ITB) 也与淋巴结扩散有关,这表明芽是关键的预后指标.

科学领域:

在瘤学瘤学.
病理学病理学病理学
癌症研究癌症研究

背景情况:

乳腺癌仍然是女性死亡的重要原因之一.
虽然分子进步有助于检测和治疗,但组织病理因素对预后至关重要.
瘤芽,以小的癌细胞为特征,与各种癌症的不良结果有关.

研究的目的:

调查瘤内芽 (ITB) 和外围瘤芽 (PTB) 与无特殊类型侵袭性乳腺癌 (IBC NST) 确定的预后因素之间的关联.
评估瘤芽的潜力作为乳腺癌的预后标志物.

主要方法:

在2020年1月至2021年12月期间诊断的70例IBC NST病例的回顾性分析.
根据每个高功率场的芽密度,瘤芽被分类为高级或低级.
评估了临床病理学数据,包括激素受体状态,Ki-67指数,淋巴血管侵袭 (LVI),围神经侵袭 (PNI) 和下淋巴结参与.
使用统计分析,包括单变量和多变量逻辑回归来确定关联.

主要成果:

高度PTB显示与LVI (p=0.046),PNI (p=0.017) 和骨淋巴结参与 (p=0.021) 有显著的关联.
高度ITB仅与状淋巴结参与有显著的相关性 (p=0.044).
在多变量分析 (p=0.017) 中,PTB与Ki-67 (p=0.012) 呈现出显著的反向关联,并且在多变量分析中持久.
在瘤芽和激素受体或更年期状态之间没有发现显著的关联.

结论:

周围瘤芽 (PTB) 与IBC NST的不良预后因素显著相关,包括LVI和淋巴结转移.
瘤内芽 (ITB) 主要与状淋巴结的参与相关.
瘤芽,特别是PTB,可以作为乳腺癌管理中的有价值的预后标志物,为临床实践提供进一步的标准化.

关键词:

在 Ki-67 机器人瘤内芽的发生侵袭性乳腺癌的癌症.周围瘤的芽开始预后参数预后参数

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