脂质代谢水平与怀孕结果之间的相关性
Jingjing Guo1, Haifan Qiu2, Jianping Wang2
1Department of Laboratory Medicine, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Frontiers in medicine
|February 27, 2025
概括
为孕妇建立脂质参考间隔有助于评估脂质代谢. 高水平的C反应蛋白,甘油三和高密度胆固醇可以预测不良的妊娠结果.
科学领域:
- 生殖医学 生殖医学
- 临床生物化学 临床生物化学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 脂肪代谢在怀孕期间发生显著的变化.
- 确定孕妇血清脂质的规范性参考间隔对于准确的临床评估至关重要.
- 了解脂质样本和怀孕结果之间的关系对于孕产妇和胎儿的健康至关重要.
研究的目的:
- 建立孕妇血清脂质指数的参考间隔.
- 调查脂质代谢标志物与不良妊娠结果之间的关联.
主要方法:
- 血清脂质概况 (TC,TG,HDL-C,LDL-C,ApoA1,ApoB,Lp(a)) 和hs-CRP在446名孕妇和317名非孕妇对照中进行测量.
- 确定了怀孕中期到晚期的脂质水平的参考范围.
- 统计分析评估了脂质水平与围产期结局之间的相关性.
主要成果:
- 怀孕不良后果与hs-CRP,TG,TC,HDL-C,LDL-C和ApoA1.1水平显著上升有关.
- 增加的hs-CRP,TG和HDL-C被确定为不良妊娠结果的危险因素.
- 使用这三个标志物的综合预测模型实现了0.822的曲线下面面积的不良结果.
结论:
- 确定的脂质参考间隔为评估孕妇的脂质代谢提供了有价值的工具.
- 监测脂质代谢,特别是hs-CRP,TG和HDL-C,可以帮助预测不良妊娠结果.
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