探索Athenaea velutina乙醇提取物的安全参数:迈向利用其药用潜力的一步
Jordana Luizi Dos Prazeres1, Alisson Andrade Almeida1, Renner Philipe Rodrigues Carvalho2
1Biochemistry and Molecular Biology, Federal University of Viçosa, Viçosa, Brazil.
Toxicological research
|February 27, 2025
概括
在老鼠中,Athenaea velutina 叶子 (Av-E) 的乙醇提取物没有显示出毒性. 这一发现支持对Av-E进行进一步的研究,以开发新的草药.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 植物化学 植物化学
背景情况:
- 巴西原产的Athenaea velutina (Av-E) 含有具有潜在抗癌和抗炎功能的维他诺化物.
- 关于Av-E的安全性和毒性存在有限的研究,阻碍了其药物开发.
研究的目的:
- 评估A. velutina叶 (Av-E) 乙醇提取物的安全性和毒性概况.
主要方法:
- 对Wistar大鼠进行了急性和亚急性毒性测试,使用不同剂量的Av-E.
- 使用HPLC-HRMS进行了植物化学分析,以确定Av-E中的化合物.
- 生物化学和组织学分析评估了潜在的肝脏和脏毒性.
主要成果:
- 在AV-E中,HPLC-HRMS确定了维他诺化类固醇.
- 急性毒性显示ALT,胆红素减少,增加.
- 亚急性毒性显示ALT和AST水平降低,在特定剂量时增加.
- 没有观察到死亡,有毒性的临床迹象,或严重的肝脏/脏损伤.
结论:
- 在动物模型中,A. velutina叶的乙醇提取物 (Av-E) 表明缺乏毒性.
- 这些安全性发现鼓励进一步调查Av-E的潜在治疗应用.
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