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José O Castellón1, Constance Yuen2,3, Brandon Han2

  • 1Biological Chemistry Department, David Geffen School of Medicine, UCLA Los Angeles CA 90095 USA kbackus@mednet.ucla.edu.

RSC chemical biology
|February 27, 2025
PubMed
概括

由于酶同质性,开发选择性酶抑制剂具有挑战性. 这项研究设计了一种新的测试方法,以发现前酶-10抑制剂,识别新的化合物类和一种乱交抑制剂.

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相关概念视频

Caspases01:24

Caspases

Caspase, a family of cysteine proteases, serve as effectors in apoptosis. The ced3 gene in C.elegans was first identified to be involved in apoptosis. This gene encodes the ced-3 caspase that is similar to the interleukin-1-beta converting enzyme or ICE in mammals. In addition to apoptosis, caspases also function in the inflammatory response. Inflammatory caspases are essential in activating pro-inflammatory cytokines that recruit immune cells and block the replication of pathogens inside cells.