明亮的夜间睡眠环境会诱导糖尿病和非人类灵长类动物的葡萄糖耐受性受损
Shuxing Wang1, Zhenyi Chen2, Zihao Liang3
1Department of Anatomy, Medical School, Foshan University, Foshan, Guangdong, China.
Frontiers in endocrinology
|February 27, 2025
概括
夜间明亮的光线暴露会恶化葡萄糖代谢,导致糖尿病和灵长类动物的葡萄糖耐受性受损. 随着年龄和体重的增加,这种效应会变得更加强烈,女性更容易受到这种影响.
科学领域:
- 代谢研究的研究.
- 内分泌学 在内分泌学.
- 灵长类动物研究.
背景情况:
- 糖尿病和葡萄糖耐受性损害 (IGT) 的全球上升需要了解促成因素.
- 与夜间光线相关的循环节律障碍和睡眠障碍被怀疑是导致葡萄糖代谢受损的因素.
- 关于夜间光线强度对灵长类动物葡萄糖代谢,糖尿病发育和基于性别的差异的确切影响的实验数据有限.
研究的目的:
- 研究夜间光线强度对非人类灵长类动物葡萄糖代谢的影响.
- 确定夜间光线与糖尿病和IGT发展之间的关系.
- 探索潜在的基于性别的差异以及衰老和体重对这些影响的影响.
主要方法:
- 197只Cynomolgus子被暴露在不同夜间光强度 (13,35,75卢克斯) 中,持续了10个月.
- 动物根据葡萄糖代谢状态进行分类:自发性糖尿病 (SDM),光诱导糖尿病 (LID),禁食葡萄糖受损 (IFG) 和正常葡萄糖耐受性 (NGT).
- 每月分析快食葡萄糖,糖化血红蛋白,血胰岛素和C-的度.
主要成果:
- 夜间的光线加剧了原生糖尿病的灵长类动物的葡萄糖代谢,导致过早死亡.
- 在健康的子中,夜间增加的光强度对剂量依赖的诱导糖尿病和IFG.
- 当与衰老和体重增加相结合时,夜间暴露于光线会协同损害葡萄糖代谢.
- 雌性灵长类动物对夜间光线的不良影响表现出更大的敏感性.
结论:
- 睡眠期间的人工光会扰乱葡萄糖代谢,加剧现有的糖尿病,并在健康灵长类动物中引发新的病例 (IFG,糖尿病).
- 夜间光线对葡萄糖调节的有害影响随着年龄的增长和体重增加而加剧.
- 女性更容易受到明亮的睡眠环境引起的代谢干扰.
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