产前抗生素暴露与婴儿喘息结果之间的关联
Rachel G Greenberg1,2, Amii M Kress3, Guojing Wu3
1Duke Clinical Research Institute, Duke University School of Medicine, Durham, North Carolina, USA.
Acta paediatrica (Oslo, Norway : 1992)
|February 27, 2025
概括
产前抗生素暴露与婴儿对咳和喘息的药物使用增加有关. 然而,它并没有增加严重呼吸系统事件的风险,例如住院治疗.
科学领域:
- 生殖健康 生殖健康
- 儿科健康 儿科健康
- 环境健康 环境健康
背景情况:
- 在怀孕期间使用抗生素是很常见的.
- 产前抗生素暴露对婴儿呼吸系统健康的影响尚未完全理解.
- 喘息和咳是婴儿常见的呼吸系统症状.
研究的目的:
- 调查怀孕期间抗生素暴露与婴儿喘息和咳之间的关联.
- 为了确定产前抗生素暴露是否会增加婴儿严重呼吸系统结果的风险.
主要方法:
- 分析了儿童健康结果环境影响 (ECHO) 队列联盟中的12个队列的数据.
- 包括4721个怀孕和4779名婴儿.
- 使用概括估计方程和后勤模型,对抗生素暴露进行反向倾向得分调整.
主要成果:
- 36%的人在怀孕期间接受了抗生素.
- 产前抗生素暴露与喘息,住院或急诊室呼吸症状访问的可能性增加无关.
- 产前抗生素暴露与使用药物治疗喘息或干咳的可能性更高 (OR=1.62,95% CI 1.10,2.38).
结论:
- 产前抗生素暴露可能与婴儿呼吸道症状的药物使用增加有关.
- 严重呼吸道事件的风险,如住院治疗,似乎不会因产前抗生素暴露而升高.
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