差异化甲状腺癌与远程转移的临床结果和预后
Chanchan Shan1, Shichen Xu2, Gangming Cai3
1Department of Oncology, Jiangyuan Hospital Affiliated to Jiangsu Institute of Nuclear Medicine, .
Nuclear medicine communications
|February 27, 2025
概括
端粒酶逆转录酶 (TERT) 促进子突变与放射性耐火分化甲状腺癌有关. 耐药性疾病的老年患者面临更高的进展风险.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 分子生物学分子生物学
背景情况:
- 差异化甲状腺癌 (DTC) 可能对放射性 (RAI) 治疗变得耐药,特别是当有远程转移时.
- 鉴定RAI耐火性 (RAIR) DTC的风险和预后因素对于患者管理至关重要.
研究的目的:
- 调查与远程转移的RAIR DTC的风险和预后因素.
- 确定RAIR的预测因子和影响这些患者疾病进展的因素.
主要方法:
- 一项队列研究包括128名患有DTC和远程转移的患者,这些患者接受了-131放射治疗.
- 75名RAIR DTC患者和53名RAI有效 (RAIE) DTC患者进行了临床数据,BRAF V600E和TERT促进器突变的比较.
- 随访RAIR-远程转移-DTC患者以评估疾病进展风险因素.
主要成果:
- TERT促进器突变,诊断时的年龄较大,瘤大小较大,淋巴结转移和转移类型与RAIR有关.
- 后勤回归确定了TERT促进子突变作为折射性的潜在危险因素.
- 在随访期间,RAIR-远程转移-DTC患者中有41例进展,24例有良好的疾病控制.
结论:
- TERT促进器突变与远程转移-DTC的RAI治疗的不良结果相关.
- 患有RAIR疾病的55岁或以上的远程转移-DTC患者有更高的进展风险.
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