环境因素触发了青春期的发展.
Sofia Malave-Ortiz1, Cameron Grant, Natalie D Shaw
1Pediatric Neuroendocrinology Group, Clinical Research Branch, National Institute of Environmental Health Sciences (NIEHS), Durham, North Carolina, USA.
Current opinion in pediatrics
|February 27, 2025
概括
环境因素越来越多地与早期的青春期有关. 研究表明,污染物,金属和压力影响生殖轴,需要进一步研究暴露水平和机制.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 环境健康 环境健康
- 发育生物学 发展生物学
背景情况:
- 在全球范围内观察到早期青春期发育的世俗趋势.
- 人们越来越担心环境因素对青春期时间的作用.
- 环境暴露对发育生殖轴的潜在影响.
研究的目的:
- 为了回顾早期青春期的世俗趋势.
- 探索环境因素在这种趋势中的潜在作用.
- 检查环境因素如何影响生殖轴.
主要方法:
- 审查最近的科学文献和流行病学研究.
- 分析拟议的机制,将环境因素与青春期的时间联系起来.
- 突出动物和人类研究的关键发现.
主要成果:
- 环境化合物可能通过性类固醇和神经受体以及表观遗传调节器影响青春期时间.
- 研究将空气污染,金属,内分泌干扰化合物 (EDC),睡眠时间,生命早期的逆境和压力与早期的青春期时间联系起来.
- 有证据表明,多种环境因素有助于改变青春期发育.
结论:
- 青春期的时间是遗传,表观遗传和环境因素的复杂相互作用.
- 虽然涉及多个环境因素,但需要进一步研究.
- 关键的暴露水平,敏感的发育窗口和潜在的机制需要阐明.
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