遗传祖先和21基因型DX乳腺癌复发得分
Peter A Borowsky1,2, Alexandra E Hernandez1,2, Susan B Kesmodel1,2
1Division of Surgical Oncology, Dewitt Daughtry Department of Surgery, University of Miami, Miami, FL, USA.
Annals of surgical oncology
|February 27, 2025
概括
祖先影响乳腺癌复发率得分 (RS). 西非血统与较高的RS有关,而东亚血统与较低的中间RS有关,这表明血统作为治疗指导的生物标志物.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 在乳腺癌的结果中观察到持续的种族和民族差异.
- 瘤型DX复发得分 (RS) 的差异可能导致这些差异,在黑人女性中发现得分更高.
- 这项研究调查了患者祖先和RS在激素受体 (HR) 阳性,人体表皮生长因子受体2 (HER2) 阴性乳腺癌中的关联.
研究的目的:
- 评估自我认同的祖先与型DX复发得分 (RS) 之间的关联.
- 探索祖先作为指导辅助治疗决策的生物生物标志物的潜力.
- 调查对HR+/HER2-乳腺瘤的测试中基于祖先的校准的需要.
主要方法:
- 具有可用的祖先和RS数据的I-III阶段HR+/HER2-乳腺癌患者的未来鉴定 (2017-2021年).
- 将RS分为低级,中级和高级的分组.
- 多位元回归分析以确定祖先和RS之间的关联,控制ER,PR和HER2表达.
主要成果:
- 西非血统显示出与中等 (OR 1.02) 和高 (OR 1.03) RS.的几率增加的显著关联.
- 东亚血统与中级RS (OR 0.78) 的几率降低有关.
- 雌激素受体 (ER),孕激素受体 (PR) 和HER2的表达增加与高RS的几率较低有关.
结论:
- 越来越多的西非祖先与中等和高RS的更高几率相关.
- 越来越多的东亚祖先与中级RS的几率较低相关.
- 研究结果表明,祖先可能作为生物生物标志物,可能需要基于祖先的校准,以指导HR+/HER2-乳腺癌的辅助治疗.
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