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Updated: May 25, 2025

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在向蛋白质降解中的PROTAC诱导的蛋白质结构动态

Kingsley Y Wu1, Ta I Hung1,2, Chia-En A Chang1

  • 1Department of Chemistry, University of California, Riverside, Riverside, United States.

eLife
|February 27, 2025
PubMed
概括

化化化 (PROTACs) 使用E3酶来降解蛋白. 这项研究揭示了PROTAC链接器动态如何影响三元复合体形成和向无处不在,影响降解效率.

关键词:
符合性采样采样药物开发是药物的发展.分子生物物理学分子生物物理学分子力学分子力学分子建模分子建模没有,没有,没有.结构生物学结构生物学结构动态 结构动态有针对性的蛋白质降解降解.

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