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生提取物促进胰腺小岛的再生在链毒素诱导的糖尿病大鼠

Manal S Abbood¹, Amani M Al-Adsani¹, Suzanne A Al-Bustan¹

¹Department of Biological Sciences, Faculty of Science, Kuwait University, Shadadiyah, Kuwait P.O. Box 5969, Safat 13060, Kuwait.

Bioscience reports

|February 27, 2025

概括

生提取物通过影响关键基因表达和恢复小岛结构,促进糖尿病大鼠胰腺β细胞再生. 这表明生可以通过刺激β细胞新生成来作为糖尿病的天然治疗方法.

科学领域:

内分泌学在内分泌学.
药理学药理学是指药理学的学科.
细胞生物学细胞生物学

背景情况:

糖尿病是一种慢性代谢障碍,其特征是高血糖.
胰腺β细胞功能障碍和损失是糖尿病发病的核心原因.
目前的治疗方法往往需要外源胰岛素,这凸显了对新型治疗策略的需求.

研究的目的:

调查生提取物 (Zingiber officinale) 诱导糖尿病大鼠功能β细胞再生的机制.
评估生提取物对参与β细胞发育和功能关键基因的表达的影响.
评估生提取物对胰腺小岛结构和β细胞质量的影响.

主要方法:

胰岛素诱导的糖尿病斯普拉格 - 达利大鼠被用水性生提取物治疗.
使用定量实时PCR分析了神经新生素-3 (Neurog3),Mafb,胰岛素2 (Ins2) 和葡萄糖 (Gcg) 的表达.
免疫组织化学分析评估了胰腺β细胞质量和小岛结构.

主要成果:

一周后,生治疗上调了Neurog3和Mafb的表达,这表明对胰腺原始体的影响.
八周后,生提取物导致Ins2和Gcg表达增加,血清胰岛素水平改善,体重增加,禁食血糖降低.
免疫组织化学检测证实,生治疗的老鼠恢复了β细胞质量和小岛结构.

结论:

生提取物通过促进β细胞新生和恢复糖尿病鼠模型中的功能来发挥抗糖尿病作用.
生作用于胰腺原生细胞和α细胞,恢复β细胞质量.
生提取物显示出作为一种天然治疗剂的潜力,用于刺激糖尿病管理中的β细胞再生.

关键词:

糖尿病糖尿病患者糖尿病患者基因表达的基因表达方式生提取物生提取物在这种情况下,胰岛素胰岛素.复兴再生是一种再生方式.β细胞的发育过程.

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