最近在韩国肉群中出现并迅速蔓延的多药耐药沙门氏菌 (Salmonella Infantis) 在韩国肉群中发生
So-Hee Lee1,2, O-Mi Lee1, Sung-Il Kang1
1Avian Disease Research Division, Animal and Plant Quarantine Agency, Gimcheon-si, Gyeongsangbuk-do, Gimcheon, Korea.
Foodborne pathogens and disease
|February 27, 2025
概括
一个在韩国肉群中的多药耐药沙门氏菌Infantis克隆显示出有关流行率的迹象. 基因分析揭示了共享的耐药基因和毒性因素,表明了潜在的国际传播和公共卫生风险.
科学领域:
- 食品安全与公共卫生问题
- 兽医微生物学 兽医微生物学
- 基因组学和传染病的研究
背景情况:
- 沙门氏菌 (Salmonella Infantis) 是家禽中普遍存在的血清型,在全球范围内越来越多地与人类沙门氏菌有关.
- 多药耐药 (MDR) 沙门氏菌对家禽生产和公共卫生构成重大威胁,因为其传播.
研究的目的:
- 在韩国肉群中识别和表征一种MDR沙门氏菌Infantis克隆.
- 探索其在家禽生产中高患病率和快速传播的遗传基础.
- 为实施针对家禽MDR沙门氏菌的有效控制措施提供见解.
主要方法:
- 从肉群中 (2020-2023) 检测220个沙门氏菌菌株的血型定型和抗菌敏感性测试.
- 使用脉冲场凝电泳 (PFGE),多位置序列类型 (MLST) 和全基因组测序 (WGS) 的遗传特征.
- 对抗微生物耐药性基因,毒性因子和家族遗传关系的分析.
主要成果:
- 确定了50种沙门氏菌幼虫菌株 (22.7%),其中46种MDR菌株对至少5种抗菌家族有抗性.
- 八种MDR菌株的WGS揭示了新兴的沙门氏菌 Infantis-like megaplasmids携带多个耐药基因的存在.
- 与国际菌株的克隆关系表明,潜在的全球传播途径是通过北美,南美和西亚传播.
结论:
- 一种具有特定遗传特征的MDR Salmonella Infantis克隆在韩国肉生产中普遍存在.
- 这些发现强调了加强生物安全和持续监测的重要性,以减轻风险.
- 有效的控制策略对于减少家禽中的沙门氏菌污染和保护公共健康至关重要.
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