甲状腺原生细胞介导的脏瘤相互作用会降低癌症免疫力
Zhi-Zhong Wu1,2, Wei-Wei Deng1,2, Su-Wen Zhu1,2
1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China.
概括
红色素原生细胞 (EPC) 连接了脏和瘤,抑制了抗瘤免疫力. 准这些EPCs可以振兴免疫反应,并提高癌症患者的免疫疗法的有效性.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 细胞生物学 细胞生物学
背景情况:
- 优化免疫疗法需要了解局部和全身免疫.
- 在瘤发育过程中系统免疫力的动态变化尚未完全理解.
研究的目的:
- 定义红色素原生细胞 (EPC) 在调解脏瘤相互作用中的作用.
- 在瘤进展过程中调查EPCs的免疫调节功能.
主要方法:
- 使用了单细胞RNA测序 (scRNA-seq) 和RNA测序 (RNA-seq).
- 分析的重点是确定EPC特征及其免疫调节作用.
主要成果:
- 瘤劫持的EPC在脏中繁殖,损害了全身和局部抗瘤反应.
- 脏CD45-EPCs通过生长因子调节CD45+EPCs的PD-L1介导免疫抑制.
- CD45+ EPCs迁移到瘤,抑制局部抗瘤免疫力,与头癌的不良预后相关.
结论:
- EPCs协调脏-瘤通信,抑制抗瘤免疫力.
- 向EPC增强了抗瘤免疫力,并提高了抗PD-L1疗法的疗效.
- EPCs代表了改善癌症免疫治疗结果的潜在治疗标.
更多相关视频
相关概念视频
Tumor Immunotherapy
461
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
461
Regulation of Hematopoietic Stem Cells
3.1K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.1K
Cell-mediated Immune Responses
66.7K
Overview
66.7K
Differentiation of Common Myeloid Progenitor Cells
3.2K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.2K
Cytotoxic T Cells-mediated Immune Response
825
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
825


