胎儿生物识别参考范围是从潜在的双胞胎群体和对不良围产期结果的评估中得出的
P Dicker1, S Daly2, R M Conroy3
1Department of Obstetrics and Gynaecology, Royal College of Surgeons in Ireland, Dublin, Ireland.
概括
确定双胞胎特定的胎儿生长参考值对于双胞胎怀孕中准确的产前评估至关重要. 使用这些量身定制的参考文献,而不是单个标准,可以更好地预测不良周产期结果.
科学领域:
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 产前超声波检查 产前超声波检查
- 胎儿成长评估 胎儿成长评估
背景情况:
- 对胎儿大小的超声波估计对于管理双胞胎怀孕至关重要.
- 目前的做法是对双胎胎的测量与单胎标准进行对比.
- 这种方法可能不准确地反映双胞胎特定的增长模式.
研究的目的:
- 专门为双胞胎怀孕建立胎儿生长参考值.
- 为了比较双胞胎与单胞胎生长参考的预测性表现,以预测不良周产期结果.
主要方法:
- 来自ESPRiT研究的前性收集数据的回顾性分析 (n=948对双胞胎).
- 使用分数多项式多层模型开发胎儿生长参考.
- 衍生双胞胎引用与现有的单元 (FMF) 和双胞胎 (FMF,STORK) 引用进行比较.
- 生物识别测量和复合不良周产期结果之间的关联分析.
主要成果:
- 双胞胎胎的生长轨迹与单体标准有显著差异,交叉点在怀孕28周左右.
- 双胞胎特异性引用与已发布的双胞胎队列 (FMF,STORK) 显示出更好的一致性,而不是单个标准.
- 双胞胎参考 (ESPRiT,STORK,FMF) 与单个参考不同,显示出具有统计学意义的关联与不良围产期结果.
结论:
- 双胞胎和单身胎儿生长模式之间存在显著差异.
- 双胞胎特异性生长参考值优于单元图表,用于评估双胞胎怀孕中的胎儿生长.
- 这项研究验证了对双胞胎特异性参考的使用,以更好地预测周产期不良结果.
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