产前大麻使用和抑郁症状
Taylor L Pitt1, Amanda A Allshouse, Pilyoung Kim
1University of Utah, Intermountain Healthcare, and Associated Regional and University Pathologists, Inc, Salt Lake City, Utah; the Department of Psychology, University of Denver, Denver, Colorado; the Department of Psychology, Ewha Womans University, Seoul, South Korea; the University of California, Irvine, Irvine, California; The Ohio State University, Columbus, and Case Western Reserve University, Cleveland, Ohio; Indiana University, Indianapolis, Indiana; the University of Pennsylvania, Philadelphia, and the University of Pittsburgh, Pittsburgh, Pennsylvania; Columbia University, New York City, New York; and East Virginia Medical School, Norfolk, Virginia.
在怀孕期间持续使用大麻,特别是在第一季度之后,与抑郁症状的增加有关. 怀孕早期大麻代谢物水平较高也与母亲晚期抑郁症状相关.
科学领域:
- 围产期心理健康问题
- 生殖毒理学 生殖毒理学
- 大麻研究 大麻研究
背景情况:
- 怀孕期间使用大麻是一个越来越令人担忧的问题.
- 了解它对母亲心理健康的影响至关重要.
- 之前的研究已经产生了关于大麻和怀孕结果的混合结果.
研究的目的:
- 调查怀孕期间大麻使用与抑郁症状之间的关联.
- 为了确定持续使用超过第一季度是否会增加抑郁症状.
- 为了探索大麻使用量与抑郁症状之间的关系.
主要方法:
- 对nuMoM2b研究的二次分析 (n=8,424).
- 大麻暴露通过尿液免疫试验评估THC-COOH.COOH.
- 使用爱丁堡产后抑郁量表 (EPDS) 在第一和第三个三个月测量抑郁症状.
主要成果:
- 任何大麻使用都与后来的抑郁症状没有显著关联 (aOR1.3,95% CI,0.97-1.6).
- 持续接触大麻超过第一季度与抑郁症状的增加有关 (aOR 1.6,95% CI,1.2-2.2).
- 第一个三个月内尿液THC-COOH水平较高与随后抑郁症状的可能性更高相关.
结论:
- 仅在头三个月内使用大麻与以后的抑郁症状无关.
- 持续使用大麻超过第一季度与抑郁症状的增加有关.
- 研究设计不允许就协会的方向性做出最终结论.
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