发生率趋势和预测肝细胞母细胞瘤儿童整体存活率的名谱:基于人口的分析分析
Kun Wang1, Shan-Shan Dong2, Wei Zhang2
1Department of Pediatric Respiratory, The First Hospital of Jilin University, Children's Hospital, Changchun, Jilin Province, 130021, China.
概括
儿科肝细胞瘤的发病率正在上升. 这项研究开发了一种使用种族和手术等风险因素进行预测预后和指导治疗的诺莫грам,从而改善患者的治疗结果.
科学领域:
- 儿科瘤学 儿科瘤学
- 癌症流行病学癌症流行病学
- 临床数据分析临床数据分析
背景情况:
- 近年来,儿科肝细胞瘤的发病率显著增加.
- 了解发病率趋势和预后因素对于有效的临床管理至关重要.
研究的目的:
- 分析2000-2018年儿科肝母细胞瘤发病率趋势.
- 确定影响肝细胞瘤预后的独立风险因素.
- 为指导临床治疗决策开发一个预测性名录.
主要方法:
- 利用SEER数据库对2000-2018年间诊断的810名儿童的临床病理学数据进行了分析.
- 使用COX,LASSO和BSR进行风险因素查和名录构造.
- 应用了X-tile软件和Kaplan-Meier方法来确定值和生存分析.
主要成果:
- 确定了种族,年龄,瘤大小,手术类型和化疗作为独立的风险因素.
- 开发的名图表显示出良好的区分能力 (AUC>0.7) 和校准.
- 决策曲线分析 (DCA) 证实了名图的临床实用性.
结论:
- 证实了儿科肝细胞瘤发病率的增加.
- 一个经过验证的名图可用于预测预后和指导治疗.
- 手术和化疗的联合治疗显示出改善生存率的前景.
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