未见但被过度计数:报告发作频率的悖论
Victoria Wong1, Timothy Hannon2, Kiran M Fernandes1
1Department of Medicine, St. Vincent's Hospital Melbourne, University of Melbourne, Parkville 3052, Australia.
Epilepsy & behavior : E&B
|February 27, 2025
概括
患者经常高估发作频率,影响治疗决策. 门诊视频EEG (avEEG) 数据显示日记比追踪发作率的调查更准确.
科学领域:
- 神经学 神经学
- 的研究研究.
- 生物医学数据分析
背景情况:
- 患者报告的发作频率对于治疗和指导抗发作药物 (ASM) 决策至关重要.
- 自我报告的主观性可能会影响治疗准确性和临床试验可靠性.
研究的目的:
- 为了比较患者报告的发作频率与电图发作频率.
- 评估不同自我报告方法 (日记与调查) 与门诊视频EEG (avEEG) 数据的准确性.
主要方法:
- 从接受家庭avEEG的患者的摄入表格和日记中收集的数据.
- 分析了EEG确诊的病例,将报告的频率与使用单变量和多变量分析的EEG数据进行比较.
主要成果:
- 每日报告的发作频率与EEG频率有很强的相关性 (p < 0.00001).
- 调查报告的频率显著高估了真正的发作率 (平均3.98次/月),与EEG数据没有相关性 (p > 0.05).
- 护理人员的存在和患者的年龄影响了报告的准确性.
结论:
- 大多数患者高估了他们的发作频率,可能导致"过度报告,过度处方"级联.
- 这些发现引发了人们对临床试验和治疗决策中自我报告的发作率可靠性的担忧.
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