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Updated: May 25, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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针对蛋白质降解的化模型

Wenxing Lv1, Xiaojuan Jia2, Bowen Tang3

  • 1Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education) of the Second Affiliated Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, 310029, China; Hangzhou Institute of Advanced Technology, Hangzhou, 310000, China.

European journal of medicinal chemistry
|February 27, 2025
PubMed
概括

计算机辅助药物设计和人工智能正在彻底改变向蛋白质降解 (TPD) 药物发现. 整合这些技术通过改进三元复杂建模,链接器生成和降解器设计来加速开发,尽管数据有限.

关键词:
链接器 链接器这是MGD MGD.建模建模模型是什么这就是PROTAC.三级复合体是一个三级复合体.

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