评估长期MRSA殖民和家庭传播:来自社区研究的见解
Taniela Marli Bes1, Robson Eduardo Soares2, Roberta Ruedas Martins2
1Hospital das Clínicas da Universidade de São Paulo, Divisão de Doenças Infecciosas, São Paulo, SP, Brazil; Instituto de Medicina Tropical da Universidade de São Paulo, São Paulo, SP, Brazil.
概括
在家庭中殖民的甲素耐药黄金葡萄球菌 (MRSA) 显示出低的传播率. 大多数无症状携带者在17个月内自发清除MRSA,皮肤疾病与持续病例有关.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 甲素耐药黄金葡萄球菌 (MRSA) 是一个重要的医疗保健相关的病原体.
- 医院传播记录得很好,但家庭传播动态的理解较少.
- 有效的预防策略需要了解MRSA在国内环境中的持久性和传播.
研究的目的:
- 评估MRSA殖民在无症状家庭携带者至少17个月的持续性.
- 调查MRSA在家庭内传播的可能性.
- 识别与MRSA清除或持续殖民相关的因素.
主要方法:
- 对7个家庭进行了家庭访问,其中至少有一个MRSA殖民成员.
- 从所有家庭成员收集了鼻子拭子,用于表型和基因型分析.
- 用培养物,抗菌素敏感性测试和PCR来表征分离物.
- 新样本与之前的样本进行了比较,以评估MRSA清除率.
主要成果:
- 在25个样本中,有14个是S. aureus,包括4个MRSA分离物.
- 最初的6例MRSA病例显示自发清除.
- 观察到MRSA的有限的家庭内传播.
- 所有家庭至少有一个成员有皮肤病史.
- 一个持续殖民的家庭有一个成员经常出现皮.
结论:
- 在家庭中MRSA殖民似乎具有有限的传播潜力.
- 在无症状携带者中,MRSA的自发清除是常见的.
- 复发性皮肤疾病可能与家庭内持续的MRSA殖民有关.
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