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Updated: May 25, 2025

Assessment of Sexual Behavior of Male Mice
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Assessment of Sexual Behavior of Male Mice

Published on: March 5, 2020

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性差异改变了C57BL/6 Tet2淘汰赛小鼠模型中的原始祖先

Samantha M Holmes1, Christopher J Wells1, Christine Hall1

  • 1Department of Biomedical and Molecular Sciences, Queen's University, Kingston, Ontario, Canada.

Experimental hematology
|February 27, 2025
PubMed
概括

与雌性相比,雄性小鼠表现出较高的关键造血干细胞和原生细胞 (HSPCs),特别是在LSK区间. 这些基于性别的HSPC差异出现,在6周至4个月之间的Tet2-缺乏模型中最明显.

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In-vitro Mutagenesis

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In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.  
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
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In animals, gender is determined by the number and type of sex chromosome. For example, human females have two X chromosomes, and males have one X and one Y chromosome, whereas C.elegans with one X chromosome is a male, and the one with two X chromosomes is a hermaphrodite.
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