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辛托克利桑通过调节血红素氧化酶通路来缓解LPS激活的巨细胞中的炎症

Jung-Yun Ahn¹, Dong-Woo Lim¹, Sung Yun Park¹

¹College of Korean Medicine, Dongguk University, Goyang, 10326, Republic of Korea.

Journal of ethnopharmacology

|February 27, 2025

概括

传统的韩国草药配方Shinhyotaklisan (SHTLS) 通过抑制关键信号通路和升级抗氧化机制,有效降低炎症. 这项研究表明它在治疗炎症疾病方面的潜力.

科学领域:

草药是一种草药.
免疫学免疫学免疫学
药理学药理学是指药理学的学科.

背景情况:

辛托克利桑 (SHTLS) 是一种传统的韩国草药配方,包括Lonicerae Flos,Astragali Radix,Angelicae Gigantis Radix,以及Glycyrrhizae Radix et Rhizoma. 这三种植物均为韩国传统的草药配方.
传统上,它通过清除热量,排毒和排出来治疗炎症性疾病.

研究的目的:

在实验室中研究SHTLS对脂聚糖 (LPS) 诱导的炎症的治疗作用.
阐明SHTLS抗炎作用的潜在机制.

主要方法:

使用30%的乙醇提取制备了SHTLS.
评估了它的抗氧化和抗微生物特性.
在暴露于LPS的RAW 264.7细胞中,使用MTT,NO,ROS测定,ELISA和西部斑点测试来评估抗炎作用.

主要成果:

SHTLS表现出显著的抗氧化和抗微生物活性.
它抑制了LPS诱导的益炎性细胞因子 (IL-6,TNF-α) 并降低了COX-2和iNOS的表达.
SHTLS抑制了NF-κB和MAPK信号通路,并上调氧酶-1 (HO-1) 表达,减少细胞内ROS和活性物种.

结论:

SHTLS具有强大的抗氧化和抗炎性质.
它的有效性与HO-1上调和NF-κB和MAPK通路的抑制有关.
SHTLS显示出作为治疗炎症相关疾病的治疗剂的希望.

关键词:

基酸 (1794427) 是一种血红蛋白氧化酶-1的使用.炎症炎症是一种炎症.通过MAPK路径.通过NF-κB路径.没有hyotaklisan一个人.

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