与Faricimab相关的眼内炎症具有疹简单病毒的特征
Imran Karim Janmohamed1, Muhammed Aizaz Us Salam2, Omer Jamall3
1Ophthalmology Department, Maidstone General Hospital (I.K.J., M.E., N.G., A.A., K.T., G.A.), Maidstone, United Kingdom.
American journal of ophthalmology
|February 27, 2025
概括
在法里西马布注射后,严重的眼内炎症 (IOI) 可能与简单疹病毒 (HSV) 再激活有关. 及时的抗病毒和类固醇治疗至关重要,尽管视力恢复可能受到限制.
科学领域:
- 眼科医生 眼科 眼科
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
背景情况:
- 法里西马布是一种针对angiopoietin-2和VEGF-A的新型双特异性抗体.
- 眼内炎症 (IOI) 是法里西马布治疗后的一个新兴问题.
- 了解严重IOI的临床特征对于患者管理至关重要.
研究的目的:
- 为了研究临床特征,管理策略和严重的IOI后faricimab的结果.
- 具体评估这些病例中暗示单纯疹病毒 (HSV) 再激活的特征.
- 探索法里西马布相关IOI的潜在机制.
主要方法:
- 追溯,单中心病例系列的五名患者 (五只眼睛) 经过法里西马布后严重的IOI.
- 患者接受了法里西马布治疗新血管与年龄相关的黄斑变性 (nAMD) 或糖尿病黄斑 (DME).
- 分析了临床数据,包括视敏度,眼内压力,前腔炎症和病毒标记物.
主要成果:
- 所有患者都呈现出前腔炎症和眼内压力升高.
- 在所有病例中都观察到HSV角膜炎的一致特征,包括树突性和粒状角膜沉物.
- 用类固醇和抗病毒药物治疗导致炎症在15.5天内消失,但80%的患者没有恢复起始视力.
结论:
- 确定了法里西马布相关IOI和HSV复兴之间的以前未报告的关联.
- 这些发现表明,眼免疫监测的改变可能起到潜在的作用,可能与VEGF-A和Ang-2抑制有关.
- 临床医生应考虑病毒机制在差异诊断和管理法里西马布相关的IOI.
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