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Updated: May 25, 2025

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癌症热点突变通过选择性排除对接相互作用来重新调节ERK2的特异性

Jaylissa Torres Robles1, Amy L Stiegler2, Titus J Boggon3

  • 1Department of Chemistry, Yale University, New Haven, Connecticut, USA; Department of Pharmacology, Yale School of Medicine, New Haven, Connecticut, USA.

The Journal of biological chemistry
|February 27, 2025
PubMed
概括

癌症相关的ERK2 (细胞外信号调节激酶2) 突变选择性地破坏特定蛋白质相互作用,改变其在瘤发育中的功能. 了解这些改变的相互作用,可以深入了解癌症机制.

关键词:
细胞信号传递是细胞的信号传递.通过基因激活的蛋白质激酶.蛋白质激酶是一种蛋白质激酶.简短的线性图案.基质特异性 基质特异性

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