ER压力和病毒防御:植物展开蛋白质响应在病变发生过程中的进展和未来前景
Binita Adhikari1, Jeanmarie Verchot1, Federica Brandizzi2
1Department of Plant Pathology and Microbiology, Texas A&M University, College Station, Texas, USA.
The Journal of biological chemistry
|February 27, 2025
概括
植物利用未折叠的蛋白质反应 (UPR) 来对抗病毒感染,这是作物生产率的关键防御机制. 需要进一步研究,以了解UPR如何调节植物病毒相互作用并确保细胞存活.
科学领域:
- 植物病理学 植物病理学
- 分子生物学分子生物学
- 农业科学 农业科学
背景情况:
- 由于病原体进化和气候变化,病毒感染越来越威胁到作物产量和农业可持续性.
- 展开的蛋白质反应 (UPR) 是细胞应激反应,由内分泌网膜过载激活,在不利条件下至关重要.
- 了解植物对病毒的防御机制,特别是UPR,对于农业的弹性至关重要.
研究的目的:
- 审查有关病毒感染的植物UPR研究的最新进展.
- 总结关于UPR如何调节植物对病毒威胁的反应的关键发现.
- 探索UPR介导的植物免疫中生存和死亡策略之间的平衡.
主要方法:
- 关于植物UPR和病毒感染的最新发现的文献综述.
- 对植物抗病毒防御中UPR调节的分子和遗传机制的分析.
- 讨论研究UPR病毒相互作用的系统级方法.
主要成果:
- 植物病毒感染迅速激活UPR,重新编程细胞过程以支持细胞活力.
- 已经确定了参与植物抗病毒防御的关键UPR监管者,但它们的确切作用仍在调查中.
- UPR激活涉及促进细胞存活和启动细胞死亡途径之间的复杂平衡.
结论:
- 通过调节细胞过程,UPR在植物防御病毒感染方面发挥着重要作用.
- 进一步的研究对于阐明植物抗病毒免疫中UPR的分子机制和功能结果至关重要.
- 系统层面的方法有望全面了解UPR在植物病毒相互作用和农业应用中的作用.
相关概念视频
The Unfolded Protein Response
4.4K
The ER is the hub of protein synthesis in a cell. It has robust systems to quality control protein folding and also for degradation of terminally misfolded proteins. Under normal conditions, a small proportion of misfolded proteins that cannot be salvaged need to be transported to the cytoplasm by the ER-associated degradation or ERAD pathways. However, if the ERAD cannot handle the misfolded proteins, the cell activates the unfolded protein response or UPR to adjust the protein folding...
4.4K
Defenses Against Pathogens and Herbivores
22.9K
Plants present a rich source of nutrients for many organisms, making it a target for herbivores and infectious agents. Plants, though lacking a proper immune system, have developed an array of constitutive and inducible defenses to fend off these attacks.
22.9K
Regulation of the Unfolded Protein Response
2.4K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.4K
Responses to Heat and Cold Stress
13.3K
Every organism has an optimum temperature range within which healthy growth and physiological functioning can occur. At the ends of this range, there will be a minimum and maximum temperature that interrupt biological processes.
13.3K
Viral Structure
61.5K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
61.5K
Stress Response System
51
The stress response system, also known as the fight-or-flight response, is the body's automatic physiological reaction to perceived threats. Hans Selye introduced the concept of General Adaptation Syndrome (GAS) to describe the predictable pattern of changes that occur in response to stress. GAS consists of three sequential stages: alarm, resistance, and exhaustion. This model helps explain how chronic stress can contribute to health problems.
Alarm stage
In the alarm stage, the body's...
Alarm stage
In the alarm stage, the body's...
51


