同时的双相异位选择性液体-液体提取,用于拉塞米分离 pantoprazole
Zhihong Yan1, En Yuan1, Yuwen Song1
1Department of Pharmacy, Jiangxi University of Chinese Medicine, Nanchang 330004, PR China.
Analytica chimica acta
|February 27, 2025
概括
这项研究增强了使用双相识别拉提取 (BRCE) 用新拉添加剂进行拉分离的酶选择性液液提取 (ELLE). 改进的 BRCE 工艺为获得像 pantoprazole 这样的光学纯化合物提供了更高的效率.
科学领域:
- 绿色化学和分离科学 绿色化学和分离科学
- 奇拉化学 奇拉化学
- 工艺工程是过程工程.
背景情况:
- 精选液液提取 (ELLE) 对于以成本效益和可持续的方式生产光学纯化合物至关重要.
- 目前的ELLE方法效率低,阻碍了大规模应用.
- 潘托普拉 (PAN) 作为一种模型化合物,用于开发先进的分离技术.
研究的目的:
- 为了提高性化合物液体-液体提取 (ELLE) 的效率.
- 调查性离子液 (CIL) 和葡萄酸 (TA) 衍生物在双相识别性提取 (BRCE) 中的协同效应.
- 优化BRCE参数,以提高酶选择性和产量.
主要方法:
- 开发了一种双相识别性提取 (BRCE) 工艺,利用性离子液体 (CIL) 作为性添加剂和酸 (TA) 衍生物作为性添加剂.
- 系统地调查了CIL/TA配置,度,温度和pH对提取性能的影响.
- 运用密度功能理论 (DFT) 计算来阐明合添加剂和潘托普拉反体之间的相互作用机制.
主要成果:
- 在优化条件下 (pH 8.0,25°C,0.3 mg/mL PAN, 1:10 [Bmim][L-Phe] 到 [D-di-isopropyl-tartrate] 的比率) 实现了优异的反选择性 (α=3.83) 和反分子过量 (即%=13.3%).
- 与现有的ELLE系统和单相识别奇拉提取 (MRCE) 相比,显著提高了提取效率.
- 证实增强的性能是由于同时双相识别R-和S-enantiomers.
结论:
- 开发的BRCE系统,结合了CIL和TA衍生品,提供了一种高效和有前途的方法来实现对抗分离.
- 这一策略为设计先进的性分离技术提供了一个强大的框架,可能与多级逆流级联系统集成.
- 这些发现为在不同条件下利用不同的立体化学偏好铺平了道路,以提高性净化.
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