MHC-I驱动的抗瘤免疫平衡剂 放射性药物治疗的低吸收剂量

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Julie Constanzo1, Aliasghar Parach2, Timothee David2

  • 1Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université de Montpellier, Nuclear Medicine Department, Institut régional du Cancer de Montpellier (ICM), Montpellier, France, and Équipe Labellisée Ligue Contre le Cancer, Paris, France; julie.constanzo@inserm.fr jean-pierre.pouget@inserm.fr.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
|February 27, 2025
PubMed
概括

主体组织相容性复合体I类 (MHC-I) 表达式通过增强T细胞免疫力来预测放射性药物治疗 (RPT) 的反应. 高MHC-I水平使得即使在较低的辐射剂量下也能够有效控制瘤,这表明基于免疫生物标志物的RPT优化.

关键词:
225AcAc225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac225Ac2T细胞适应性免疫的适应性免疫通过旁观者免疫力.微观环境是一个微观环境.放射性免疫疗法是一种放射性免疫疗法.有针对性的放射性核酸治疗.

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