相关实验视频
Updated: May 25, 2025

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
在顶级医学出版物中不充分报道随机临床试验的危害
Rui Zheng1,2, Liyuan Tao3,4, Yang Sun1
1Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.
随机对照试验 (RCT) 中的危害报告在顶级医学期刊中不足. 更好地遵守CONSORT Harm等报告准则对于基于证据的决策至关重要.
科学领域:
- 临床研究 临床研究
- 医学杂志 出版 出版 出版
- 基于证据的医学基于证据的医学.
背景情况:
- 高影响力的通用医学期刊发表了众多随机对照试验 (RCT).
- 在RCT中准确报告患者的伤害对于临床决策和患者安全至关重要.
- 在RCT中报告危害的现有框架需要一致的应用.
研究的目的:
- 评估在领先的一般医学期刊上发表的RCT中有害性报告的质量.
- 发现已发表的RCT中不良事件和危害的呈现和讨论方式的缺陷.
主要方法:
- 在2022年1月至2023年12月期间在五个具有影响力的一般医学期刊中发表的RCT的系统审查.
- 数据提取侧重于伤害的呈现和讨论,使用CONSORT伤害框架进行分析.
- 包括RCT比较药物与安慰剂对照.
主要成果:
- 分析了175个RCT;没有一个引用了CONSORT Harms 2004声明.
- 发现了显著的缺陷:71%的损害数据收集方法被遗漏,86.3%仅使用描述性统计数据进行分析,45.1%未能讨论利益和危害的平衡.
- 常见的局限性包括不清楚的方法,选择性报告和不充分的分析.
结论:
- 顶级期刊的RCT在危害报告中表现出重大缺陷.
- 更新的CONSORT Harm 2022声明提供了一个实际的工具,需要在研究人员,审稿人和编辑中积极推广.
- 为了支持明智的临床决策,需要加强RCT中有害性报告标准.
更多相关视频
06:55Inverse Probability of Treatment Weighting Propensity Score using the Military Health System Data Repository and National Death Index
Published on: January 8, 2020
07:50A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
相关概念视频
Clinical Trials
There are four phases in a clinical trial. A phase one...
Hazard Ratio
For example, in a clinical trial...
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast,...
Types of Reports II: Incident or Occurrence Report
Purposes:
In the healthcare industry, reports play a crucial role in documenting incidents within an agency. The primary objective of these reports is to ensure patient safety, uphold the...
Types of Reports III: Telephone and Verbal Reports
Here's an overview of each type:
Telephone Orders
Errors occurring during blood pressure monitoring
Several factors...