在日本非肥胖人口中,TyG相关参数与NAFLD风险之间的关联
Xiuli Wang1, Jie Liu2, Ke Yu3
1Department of Gastroenterology, The First People's Hospital of Chenzhou, Chenzhou, 423001, China.
Scientific reports
|February 27, 2025
概括
在非肥胖个体中,非酒精性脂肪性肝病 (NAFLD) 经常被忽视. 与甘油三糖 (TyG) 相关的参数显示与NAFLD风险的非线性关联,并提供预测价值,特别是在女性中.
科学领域:
- 代谢综合征是代谢综合征的一种.
- 肝病学 肝病学是一种肝病学.
- 公共卫生 公共卫生
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 影响着大量非肥胖人口,经常被忽视.
- 在非肥胖的NAFLD中,关于与甘油三糖 (TyG) 相关的参数的研究有限.
- 在这个人口群体中,对NAFLD的早期检测和干预策略至关重要.
研究的目的:
- 研究与TyG相关的参数 (TyG-BMI,TyG-WC,TyG-WHtR) 与非肥胖个体的NAFLD之间的关联.
- 加强对非肥胖人口中NAFLD的早期发现和干预.
- 探索这些参数的潜在非线性关系和预测性能.
主要方法:
- 从NAFLD数据库 (2004-2015) 中对11,987名参与者的横截面分析.
- 逻辑回归模型具有立方斜线函数和平滑曲线拟合.
- 接收器运行特征 (ROC) 曲线分析以评估预测性能.
主要成果:
- 较高的TyG相关参数与非肥胖个体中NAFLD发病率增加相关.
- 在TyG指数/相关参数和NAFLD风险之间确定了非线性关系.
- ROC分析显示预测能力 (AUC:0.7984-0.8584),在女性中更强.
结论:
- 在非肥胖个体中,与TyG相关的参数和NAFLD风险之间存在积极的非线性关系.
- 与TyG相关的参数显示了NAFLD的预测价值,仅仅超过TyG指数.
- 这些发现支持使用TyG相关的参数来早期检测非肥胖人群的NAFLD,特别是女性.
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