患有恶性瘤的患者中败血症的临床特征和预后因素
Green Hong1, Hyekyeong Ju1, Dong Kyu Oh2
1Division of Allergy, Pulmonary, and Critical Care Medicine, Department of Internal Medicine, Chungnam National School of Medicine, Chungnam National University Hospital, Munhwaro 282, Jung Gu, Daejeon, 35015, Republic of Korea.
Scientific reports
|February 27, 2025
概括
癌症患者的败血症是致命的,死亡率为35%. 糟糕的结果与器官功能障碍,重症监护需求以及较少遵守败血症护理包有关,特别是在像Gram阴性细菌这样的感染中.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 败血症在患有恶性瘤的患者中是一个重大挑战,导致高死亡率和重症监护室 (ICU) 住院人数增加.
- 了解特定的临床特征和预测结果的因素对于改善这种脆弱人群的生存至关重要.
研究的目的:
- 为了研究癌症患者的败血症的临床特征.
- 确定与败血症结局相关的预后因素,包括30天和住院死亡率.
主要方法:
- 一项全国性的多中心队列研究,涉及4,858名癌症患者,从2019年9月至2020年2月被诊断患有败血症.
- 考克斯回归分析被用来确定死亡率的预测因素.
主要成果:
- 总体生存率为65%,死亡率为35%. 不幸存者更频繁地需要重症监护干预,如机械呼吸和连续脏替代疗法.
- 死亡率的预测因素包括功能障碍,序列器官衰竭评估 (SOFA) 评分升高以及对维持生命治疗的依赖.
- 在非幸存者中,观察到对败血症护理包,特别是后期干预措施的遵守程度较低. 在那些没有存活下来的人中,阴性细菌感染和多药性耐药性更为常见.
结论:
- 考虑到个体患者和疾病因素的量身定制的治疗策略对于治疗癌症患者的败血症至关重要.
- 早期检测和器官功能障碍的管理,以及严格遵守败血症协议,对于提高这一群体的生存率至关重要.
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