前临床前额叶皮质介导了持续的社会回避的发展,这是由于社会威胁条件的结果
Kelly Lozano-Ortiz1,2, Ada C Felix-Ortiz1,2,3, Jaelyn M Terrell1,2
1Department of Neuroscience, Developmental, and Regenerative Biology, The University of Texas at San Antonio, San Antonio, TX, USA.
概括
社会创伤可以通过在大脑中启动学习机制,导致持续的社会回避. 在创伤期间沉默特定的前额叶皮层区域可以防止这种回避行为.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 创伤研究 创伤研究
背景情况:
- 社会回避是一个重要的行为问题,其潜在机制不明确,特别是在社会创伤后.
- 了解社会相关的创伤经历是如何导致社会回避的,对于开发有效的干预措施至关重要.
研究的目的:
- 研究神经生物学机制,通过这些神经生物学机制,社会威胁条件诱导社会回避.
- 确定特定的大脑区域和分子途径,参与社会回避的发展和潜在的逆转.
主要方法:
- 研究人员使用了一种小鼠模型来确定社会威胁的条件,在社会探索过程中使用冲击惩罚.
- 在特定的前额叶皮层 (PFC) 亚区域 (前膜皮层 - PL,下膜皮层 - IL) 中使用光遗传沉默和NMDAR抑制.
- 进行了社交性测试,以评估在条件化和干预之前和之后的社会行为.
主要成果:
- 社会威胁条件强烈诱导持续的社会回避,独立于背景,性别或特定的社会伙伴.
- 在条件化过程中,对前临床皮层 (PL) 的光遗传性沉默阻止了社会回避的发展.
- 在PL中抑制NMDAR也阻止了社会威胁对社会行为的长期影响.
结论:
- 与社会相关的创伤是社会回避的重要风险因素.
- 皮质膜网络中的学习机制,特别是PL,对于形成长期的社会威胁表征至关重要.
- 针对PL介导的学习途径提供了潜在的治疗策略,以避免因创伤而产生的社会行为.
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