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尿液均水平与癌症之间的反转U形关联:基于全国人口的横截面研究

Jufa Li¹, Jing Lv¹, Yuwei Zhang^2,3

¹Wuxi School of Medicine, Jiangnan University, Wuxi, China.

Scientific reports

|February 27, 2025

概括

这项研究发现,更高的尿液等度与40岁及以上美国人的癌症风险增加有关. 然而,非常高的水平可能会显示出轻微的保护作用,需要进一步调查.

科学领域:

生物化学生物化学
营养科学营养科学
流行病学流行病学

背景情况:

来自大豆的植物性雌激素Equol具有潜在的健康益处,但其在癌症预防中的作用仍在争论中.
肠道细菌将大豆异黄代谢成equol,其个体产量各不相同.
现有的关于equol和癌症风险的研究提出了相互矛盾的发现.

研究的目的:

为了研究尿液等值度与美国成年人群癌症风险之间的关联.
为了分析equol水平和癌症发病率之间的剂量反应关系.
探索潜在的非线性关联和值效应.

主要方法:

利用了2005-2010年国家健康和营养检查调查 (NHANES) 中2797名参与者 (40岁以上) 的数据.
采用加权后勤回归,分层分析和光滑曲线拟合来分析癌症风险.
评估癌症诊断与尿液等度的四分位数,并进行值效应分析.

主要成果:

在更高的尿液等值水平和增加的癌症风险之间观察到正相关性.
与最低四分位数相比,同醇分泌的最高四分位数显示癌症风险增加了25.4% (POR=1.254).
平的曲线拟合揭示了一个反转的U形关系,风险增加到25.5 ng/ml以下,略微降低到以上.

结论:

尿液中乙醇度升高与美国成年人患癌症的风险更高有关.
存在潜在的值效应,低于25.5 ng/ml的度与风险增加有关.
需要进一步的前性研究和临床试验来证实这些发现,并阐明equol与癌症之间的复杂关系.

关键词:

癌症风险癌症风险癌症风险在Equol中使用Equol.肠道代谢物的代谢物.尼汉斯 (NHANES) 是一个名人.这就是大豆大豆.尿液尿液尿液

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