在70岁以上的BRCA1/2突变载体中,高风险监测MRI可能不需要
Astrid Botty van den Bruele1,2, Yi Ren3, Samantha M Thomas3,4
1Surgical Oncology, Department of Surgery, Duke University, DUMC 3513, Durham, NC, 27710, USA. Astrid.Botty@duke.edu.
Breast cancer research and treatment
|February 27, 2025
概括
对于70岁及以上具有BRCA1/2突变的女性,乳房图片可能足以用于乳腺癌监测. 这表明个性化护理和潜在的较老的载体可能不那么密集的查.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 放射学 放射学是一门学科.
背景情况:
- 患有BRCA1/2突变的女性一生患乳腺癌的风险很高 (69-72%至80岁).
- 乳腺癌的风险估计在晚年变得不那么可靠.
- 许多没有乳腺癌的老年BRCA1/2携带者都接受密集监测.
研究的目的:
- 为了评估70岁及以上具有BRCA1/2突变的女性的乳腺癌诊断.
- 为了确定负责诊断恶性瘤在这个年龄组的成像模式.
主要方法:
- 在1996年至2022年期间诊断出BRCA1/2突变的女性的回顾性审查.
- 根据BRCA1/2诊断时的年龄分层的队列:30-59岁,60-69岁和≥70岁.
- 记录了恶性瘤的数量和用于诊断的成像方式.
主要成果:
- 在316名患者中,15名 (4.7%) 在基因检测时年龄≥70岁.
- 乳腺恶性瘤被诊断在40%的70岁以上的患者中,相比之下是60.5% (30-59) 和31.4% (60-69).
- 在70岁以上的乳腺癌患者中,66.7%的乳腺癌通过乳房影像检测到.
结论:
- 乳腺扫描可能适用于70岁以上的BRCA1/2突变女性的乳腺癌监测.
- 对于较老的BRCA1/2携带者,应考虑个性化护理和降级监测.
- 这种方法承认,一些老年携带者可能不会患乳腺癌.
相关概念视频
Imaging Studies I: CT and MRI
164
Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...
164
Radiological Investigation II: MRI and Ventilation Perfusion Scan
93
Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
93
Magnetic Resonance Imaging
4.9K
Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...
4.9K
Radiological Investigation I: X-ray and CT
198
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
198


