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Updated: May 25, 2025

Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
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Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

Published on: August 9, 2019

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阿普塔默辅助DNA SELEX:单一蛋白质的双位点向

Achut Prasad Silwal1, Siddhartha Kalpa Samadhi Thennakoon1, Raunak Jahan1

  • 1Department of Chemistry and Center for Photochemical Sciences, Bowling Green State University, Bowling Green, Ohio 43403, United States.

ACS biomaterials science & engineering
|February 28, 2025
PubMed
概括

研究人员开发了一种新方法,即Aptamer-Assisted DNA SELEX (AADS),用于创建针对编程死亡合体1 (PD-L1) 的融合合体. 这些体有效抑制PD-1/PD-L1相互作用,显示癌症治疗的希望.

关键词:
这就是AADSS AADS.PD-1/PD-L1 相互作用聚变吸收体的融合器

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Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
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