Hs-CRP/ALB水平与接受皮肤冠状动脉干预的STEMI患者的长期预后不佳有关
Mingyang Li1,2, Yan Zhang3, Xiaodong Cui1,2
1Clinical School of Thoracic, Tianjin Medical University, Tianjin, China.
Angiology
|February 28, 2025
概括
高灵敏度C反应蛋白 (hs-CRP) /白蛋白 (ALB) 的比率与穿皮冠状动脉干预 (PCI) 后ST段升高心肌梗塞 (STEMI) 患者的较差结果有关. 这种炎症标志物预测了主要的不良心血管事件和死亡率,表明长期预后不佳.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 临床研究 临床研究
背景情况:
- 炎症生物标志物,包括hs-CRP/ALB比率,正在研究它们在心血管疾病中的预后价值.
- 在ST段升高心肌梗塞 (STEMI) 患者中hs-CRP/ALB比率与预后之间的关联需要进一步调查.
研究的目的:
- 调查hs-CRP/ALB比率与PCI治疗的STEMI患者的长期预后之间的独立关联.
- 评估hs-CRP/ALB比率对主要心血管不良事件 (MACE) 和所有原因死亡率的预测能力.
主要方法:
- 这是一项回顾性队列研究,涉及752名在2017年1月至2018年12月期间接受PCI的STEMI患者.
- 考克斯回归分析用于评估hs-CRP/ALB比率与MACE和全因死亡率的关联.
- 接收器操作特征 (ROC) 曲线分析确定了hs-CRP/ALB比率对总死亡率的预测能力.
主要成果:
- 在52个月的中位数随访期间,24.0%的患者经历了MACE,10%的患者死亡.
- hs-CRP/ALB比率与MACE (连续HR 1.152,分类HR 1.257) 和所有原因死亡率 (连续HR 1.119,分类HR 2.228) 独立相关.
- hs-CRP/ALB比率显示出对整体死亡率的预测能力,AUC为0.68.
结论:
- hs-CRP/ALB比率是接受PCI的STEMI患者长期预后不佳的独立预测指标.
- 升高的hs-CRP/ALB水平与严重心血管不良事件的风险增加以及所有原因的死亡率有关.
- 在PCI后的STEMI患者中,hs-CRP/ALB比率可以作为一个有价值的预后生物标志物.
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