一只2天大的羊羔的肠毒症是由D型羊羔毒素阳性菌株Clostridium perfringens产生的
Kaylin Moctezuma1, Hernando D Acevedo2, Eileen E Henderson2
1Department of Pathology, SoBran, Silver Spring, MD, USA.
概括
类型D的克洛斯特里透会导致肠毒性病. 一个羔羊病例表明,lambda毒素激活了epsilon毒素,导致新生儿患病,挑战了传统信仰.
科学领域:
- 兽医微生物学 兽医微生物学
- 病理学 病理学 病理学
- 细菌毒理学 细菌毒理学
背景情况:
- 类型D的克洛斯特里透会在牲畜中引起肠毒性病.
- 胃中毒症涉及α (CPA) 和epsilon (ETX) 毒素.
- 新生儿的敏感性传统上被认为是低的,这是由于乳牛奶的素抑制.
研究的目的:
- 在新生儿羔羊中调查致命的肠毒性病例.
- 确定引起病原体和涉及的毒素.
- 探索年轻动物疾病的潜在机制.
主要方法:
- 对一只死去的羊羔进行尸检和诊断工作.
- 隔离和识别Clostridium perfringens类型D. 的情况.
- 在肠道中检测毒素 (CPA,ETX) 和相关基因 (lambda毒素).
主要成果:
- 单独从羔羊的肠道中分离出了D型菌.
- 检测到了α毒素 (CPA) 和epsilon毒素 (ETX).
- 兰巴达毒素基因存在,表明其作为蛋白酶的作用.
结论:
- 一只新生儿的羔羊死于Clostridium perfringens D型肠毒症.
- 兰巴毒素可能会在肠道中激活epsilon原毒素 (pETX).
- 这个案子挑战了新生儿对D型肠毒性病的耐药性概念.
相关概念视频
Bacterial Phylum Spirochaetes
1.5K
Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased...
1.5K
Bacterial Phylum Actinobacteria
854
Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
854
Reservoir of Infection
89
Infectious diseases arise from intricate interactions between pathogens and their reservoirs. A reservoir of infection refers to the natural habitat where a pathogen lives, grows, and multiplies, serving as a continual source of infection. Reservoirs are broadly classified as either living or nonliving, and each plays a unique role in disease transmission, significantly influencing public health interventions and control strategies.Humans act as reservoirs for a wide array of pathogens,...
89
Diphtheria
175
Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
175
Atypical Pneumonia
84
Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease...
84
Bacterial Gastroenteritis
88
Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
88


