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Updated: May 25, 2025

Generation of Genomic Deletions in Mammalian Cell Lines via CRISPR/Cas9
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Generation of Genomic Deletions in Mammalian Cell Lines via CRISPR/Cas9

Published on: January 3, 2015

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[在β-环球蛋白基因集群中发现罕见的3.5kb删除]

Yun-Hua Fan1, Cui-Lin Duan2,3, Sai-Li Luo1

  • 1Department of Clinical Laboratory Examination, People's Hospital of Dehong Prefecture, Mangshi 678400, Yunnan Province, China.

Zhongguo shi yan xue ye xue za zhi
|February 28, 2025
PubMed
概括

在β-环球蛋白基因集群中罕见的3.5kb删除可以导致轻度贫血. 复合突变,包括这种删除,可能导致中度至重度的β-thalassemia,突出显示在疑似病例中需要进行基因检测.

关键词:
贝塔血症;遗传性疾病;基因突变;遗传检测.

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Exon Recombination02:32

Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
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