非编码RNA对黑色素瘤编程细胞死亡的调控效应:针对性治疗的新型治疗交叉
Andarz Fazlollahpour-Naghibi1, Seyed Reza Taha2, Mahdieh Shariatzadeh2
1Faculty of Medicine, Islamic Azad University, Sari Branch, Sari, Iran.
Current cancer drug targets
|February 28, 2025
概括
非编码RNAs (ncRNAs) 和编程细胞死亡 (PCD) 在黑色素瘤的发展中至关重要. 了解它们的相互作用为这种侵袭性皮肤癌提供了新的向治疗选择.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 遗传学 遗传学 是一个
背景情况:
- 皮肤黑色素瘤是一种侵袭性皮肤癌,在全球范围内发病率不断增加.
- 早期诊断和有效的向治疗仍然是黑色素瘤管理的关键挑战.
- 非编码RNAs (ncRNAs),包括microRNAs和长非编码RNAs,由于它们在细胞过程中的调节作用,涉及黑色素瘤病变发生.
研究的目的:
- 审查与编程细胞死亡 (PCD) 相关的非编码RNAs (ncRNAs) 在皮肤黑色素瘤中的作用.
- 探索ncRNAs和PCD之间的相互作用作为黑色素瘤的潜在治疗策略.
- 专注于参与黑色素瘤中ncRNA介导PCD的潜在分子通路.
主要方法:
- 在皮肤黑色素瘤中对ncRNAs和PCD的最新研究的文献综述.
- 对专注于黑色素瘤发病过程中ncRNAs失调的研究进行分析.
- 检查将PCD途径与黑色素瘤开始和进展联系在一起的研究.
主要成果:
- 对ncRNAs的失调是黑色素瘤发展的重要因素.
- 编程细胞死亡 (PCD) 在皮肤黑色素瘤的开始和进展中起着至关重要的作用.
- ncRNAs和PCD通路之间的相互作用为新型黑色素瘤疗法提供了一个有前途的途径.
结论:
- ncRNAs是黑色素瘤的关键调节者,它们的调节失调有助于这种疾病.
- PCD机制从根本上参与了黑色素瘤的生命周期.
- 针对ncRNAs和PCD之间的相互作用,为黑色素瘤治疗提供了一个新的治疗策略.
相关概念视频
01:31The Intrinsic Apoptotic Pathway
5.9K
Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
5.9K
02:57Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
01:22MicroRNAs
3.0K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
02:39lncRNA - Long Non-coding RNAs
8.5K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.5K
01:17The Extrinsic Apoptotic Pathway
5.8K
The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
5.8K
02:15Experimental RNAi
6.0K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.0K