韩国女性良性甲状腺疾病与乳腺癌风险之间的关联
Boyoung Park1,2, Thi Xuan Mai Tran1,3
1Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea.
Cancer research and treatment
|February 28, 2025
概括
这项研究发现,甲状腺结节和甲状腺功能障碍与韩国妇女患乳腺癌 (BC) 的风险增加有关. 然而,甲状腺功能低下症与BC风险没有显著联系.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 甲状腺疾病很常见,可能会影响癌症风险.
- 了解甲状腺功能与乳腺癌 (BC) 之间的关系对于风险评估和预防策略至关重要.
研究的目的:
- 调查甲状腺疾病 (结节,甲状腺功能低下,甲状腺功能过高) 与在一大批韩国妇女中患乳腺癌 (BC) 的风险之间的关联.
主要方法:
- 使用韩国国家医疗保险数据 (2009-2010) 进行的回顾性队列研究.
- 包括40岁以上的女性,接受BC检查.
- 通过ICD-10代码识别的甲状腺疾病;追踪到2021年的BC病例.
- 考克斯回归分析评估了BC风险;物流回归分析了风险因素关联.
主要成果:
- 在超过500万女性中,甲状腺结节 (2.5%) 和甲状腺功能过高 (0.9%) 与显著增加的BC风险有关 (HR分别为1.16和1.13).
- 甲状腺功能低下 (1.8%) 与BC风险没有显著关联 (HR 0.98).
- 与结节和甲状腺功能障碍相关的BC风险增加在绝经前和绝经后的女性中都观察到.
结论:
- 甲状腺结节和甲状腺功能过高的病史与乳腺癌 (BC) 的风险增加有关.
- 甲状腺功能低下症和BC风险之间没有发现显著的关联.
- 这些发现强调了在评估乳腺癌风险时考虑甲状腺健康的重要性.
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