评估地中海,停止高血压的饮食方法和中海-DASH干预神经退行性延迟饮食模式,结构连接和认知功能之间的关联
Lizanne Arnoldy1, Sarah Gauci1,2, Lauren M Young3
1Centre for Mental Health and Brain Sciences, Swinburne University, Melbourne, Australia.
The British journal of nutrition
|February 28, 2025
概括
这项研究发现地中海,DASH或MIND饮食与中年或老年人大脑健康或认知功能的改善之间没有强烈的联系. 建议对纵向设计进行进一步的研究.
科学领域:
- 神经科学是一个神经科学.
- 营养科学 营养科学
- 老年学是一门学科.
背景情况:
- 全球人口老龄化正面临神经退行性疾病的上升.
- 饮食是一种可修改的危险因素,但其对大脑衰老和认知的影响尚不清楚.
- 不一致的神经成像结果突出了理解饮食与大脑相互作用的差距.
研究的目的:
- 调查地中海,DASH和MIND饮食与认知功能和大脑连接的关联.
- 评估饮食对大脑结构和认知表现的影响,健康的中年和老年人的认知能力下降.
- 探索饮食模式如何影响白质完整性和大脑网络组织.
主要方法:
- 涉及健康的中年人 (n=52) 和患有主观认知衰退的老年人 (n=55) 的横截面研究.
- 认知评估和扩散权重的MRI被用来分析大脑结构和白质完整性.
- 基于网络的统计分析了基于饮食坚持水平的大脑子网络和连接.
主要成果:
- 年龄与两个队伍的认知功能和全球大脑指标负相关.
- 在共变量调整后,在坚持地中海,DASH或MIND饮食时,没有观察到认知或全球大脑指标的显著改善.
- 在主观认知衰退队列中,基于DASH饮食的坚持,发现了大脑子网络的差异.
- 减少MIND和DASH饮食的坚持与健康队列中较低的白质连接性有关.
结论:
- 该研究没有发现强有力的证据表明,遵守地中海,DASH或MIND饮食与改善认知功能或大脑连接性有关.
- 饮食模式的坚持没有显示出与研究群体的认知或大脑结果的显著关联.
- 未来的研究应该采用纵向设计和精细的饮食评估方法,以更好地了解饮食在大脑衰老中的作用.
更多相关视频
09:38Generalized Psychophysiological Interaction PPI Analysis of Memory Related Connectivity in Individuals at Genetic Risk for Alzheimer's Disease
Published on: November 14, 2017
14.8K
08:43Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment
Published on: August 7, 2017
7.8K
相关概念视频
Alzheimer's Disease: Overview
1.7K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.7K
Atherosclerosis III: Management
747
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
747
Dementia
693
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
693
Attention-Deficit/Hyperactivity Disorder
1.4K
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
1.4K
Dementia l: Introduction
35
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
35
