近红外纳米温度计揭示了器官和身体表面之间的温度差异,用于预防热中风
Meilin Liu1, Yaru Sun1, Yi Zhang1
1Department of Medical Biochemistry and Molecular Biology, School of Medicine, Jinan University, Guangzhou, Guangdong 510632, China.
Nano letters
|February 28, 2025
概括
一个新的近红外纳米温度计准确地测量热中风期间的器官温度. 这种工具显示肝脏温度高于直肠温度,这表明热中风损伤开始于比以前认为的更低的温度.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 生理学 生理学 生理学
背景情况:
- 在热中风期间,器官温度可能与表面温度显著不同,可能导致急性器官衰竭.
- 目前的方法缺乏用于实时监测器官温度的非侵入性技术,从而掩盖温度差异.
研究的目的:
- 开发一种新的近红外发射纳米温度计,用于准确的,非侵入性的器官温度监测.
- 在热中风期间调查器官和核心体温之间的温度差异.
主要方法:
- 开发了一种使用Nd3+和Yb3+编码的纳米温度计,用于在808nm激发下进行双近红外辐射 (980和1330nm).
- 利用排放的不同温度反应来构建用于温度检测的比度纳米探测器.
- 在小鼠中静脉注射纳米探针,以实时监测肝脏温度.
主要成果:
- 纳米温度计证明了温度依赖的双重排放,使得准确的比度温度传感.
- 纳米探针在小鼠肝脏中迅速积累,显示肝脏温度始终比直肠温度高1.5°C.
- 在直肠温度为42°C时观察到肝损伤的开始,挑战热中风模型中传统的43°C值.
结论:
- 推出了一种强大的近红外纳米温度计,用于精确测量器官温度.
- 热中风期间有显著的器官核心温度差异,影响损伤发病评估.
- 这项技术为了解和诊断与热有关的疾病提供了一种新的方法.
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