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神经成像在感染艾滋病毒的个体中神经认知障碍方面取得了进展

Han Wang^1,2, Xiaolin Jiu¹, Zihua Wang³

¹Department of Radiology, Bethune International Peace Hospital (the 980th Hospital of PLA Joint Logistic Support Force), Shijiazhuang, Hebei, China.

Frontiers in neurology

|February 28, 2025

概括

联合抗逆转录病毒疗法 (cART) 可以延长艾滋病毒患者的寿命,但神经认知障碍 (HAND) 的风险仍然存在. 本综述探讨了磁共振成像 (MRI) 技术如何帮助理解艾滋病毒.

科学领域:

神经成像是一种神经成像.
神经学神经学
传染性疾病传染性疾病

背景情况:

联合抗逆转录病毒疗法 (cART) 延长了人类免疫缺陷病毒 (HIV) 患者的生存期.
尽管治疗有效,但艾滋病毒患者面临显著更高的神经认知障碍的风险,称为艾滋病毒相关的神经认知障碍 (HAND).
磁共振成像 (MRI) 对于评估大脑结构和功能至关重要.

研究的目的:

对艾滋病毒感染个体的各种基于MRI的神经成像技术的应用进行审查.
用先进的成像方法了解与艾滋病毒感染相关的神经变化.

主要方法:

在HIV.功能性MRI (fMRI) 应用的审查.
对艾滋病毒的结构性MRI发现的分析.
在艾滋病毒研究中探索扩散MRI和定量MRI.
讨论多模态MRI方法和先进的神经成像分析.

主要成果:

功能性核磁共振,结构性核磁共振,扩散核磁共振和定量核磁共振已经推动了对艾滋病毒相关神经变化的理解.
这些技术提供了对HIV的脑功能和结构改变的见解.

结论:

多模态MRI与先进的分析方法相结合,有望确定艾滋病毒认知障碍的驱动因素.
需要进一步的研究,以充分阐明HAND背后的机制,使用全面的神经成像策略.

关键词:

与艾滋病毒相关的神经认知障碍扩散磁共振成像技术的使用.功能性磁共振成像技术功能性磁共振成像技术定量磁共振成像技术的使用.结构磁共振成像结构磁共振成像

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