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Updated: May 25, 2025

Analysis of Retinoic Acid-induced Neural Differentiation of Mouse Embryonic Stem Cells in Two and Three-dimensional Embryoid Bodies
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恩特雷克提尼布可以通过抑制PI3K-AKT和TGF-β信号通路来诱导神经细胞损伤

Qingshan Tang1, Jiachen Dong1, Feng Zhang1

  • 1Jiangsu Key Laboratory, Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China.

Frontiers in pharmacology
|February 28, 2025
PubMed
概括

恩特雷克提尼布通过降低THBS1的调节和抑制PI3K-AKT/TGF-β通路而导致神经细胞损伤. 过度表达THBS1可以挽救这些因特雷克提尼布引起的毒性,提供潜在的治疗点.

关键词:
这就是Pi3k-akt.在TGF-β的基础上.在THBS1中,THBS1是THBS1.恩德雷克提尼布 (Entrectinib) 是一种药物.神经细胞损伤的神经细胞损伤.

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