影响人类大脑解剖学 人类大脑解剖学
Lucia Lopez-Chaichio1, Pablo Galindo-Moreno2, Miguel Padial-Molina2
1Private practice, Jaen, Spain. Formerly PhD Program in Clinical Medicine and Public Health, University of Granada, GranadaSpain.
Journal of oral & maxillofacial research
|February 28, 2025
概括
口腔中的功能性闭合对较少,与大脑物质体积和大脑皮层厚度的减少有关. 这种关联可能会影响对阿尔茨海默病和痴呆症进展至关重要的区域.
科学领域:
- 神经科学是一个神经科学.
- 牙科医学 牙科医学
- 放射学 放射学是一门学科.
背景情况:
- 大脑结构和体积是认知健康的关键指标.
- 牙堵塞,牙的对齐,可能会影响全身健康.
- 以前的研究还没有广泛探索牙堵塞与大脑解剖学之间的联系.
研究的目的:
- 调查功能性闭合对数量与大脑解剖学变化之间的关系.
- 评估白质量,灰质量和大脑皮层厚度与闭塞状态之间的相关性.
主要方法:
- 观察性临床研究涉及70名患者.
- 使用磁共振成像 (MRI) 进行非侵入性脑部分析.
- 使用SPM12和CAT12软件量化灰质,白质和皮质厚度;通过斯皮尔曼相关和多重回归进行统计分析.
主要成果:
- 较少的功能性闭塞对数与特定大脑区域 (例如外部囊) 白质体积减少有显著的相关性.
- 在包括圈和小脑在内的区域观察到减少灰质体积.
- 大脑皮层厚度下降,特别是在额叶皮层,与较少的闭合对有关.
结论:
- 功能性闭塞对的数量与大脑的结构完整性有关.
- 研究结果表明,口腔健康 (闭塞) 和与阿尔茨海默氏症等神经退行性疾病相关的大脑区域之间存在潜在联系.
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